Title : Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice.

Pub. Date : 2019 Jul

PMID : 30470795






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Elevated MCL-1 or BCL-2 reduced sensitivity to daunorubicin but, surprisingly, not to bortezomib. Daunorubicin BCL2 apoptosis regulator Homo sapiens
2 Notable synergies were achieved by combining BH3 mimetics with daunorubicin: S63845 increased the sensitivity of both MCL-1 and BCL-2 overexpressing MLL-AF9 AMLs, and ABT-737 aided in killing those overexpressing BCL-2. Daunorubicin BCL2 apoptosis regulator Homo sapiens
3 Notable synergies were achieved by combining BH3 mimetics with daunorubicin: S63845 increased the sensitivity of both MCL-1 and BCL-2 overexpressing MLL-AF9 AMLs, and ABT-737 aided in killing those overexpressing BCL-2. Daunorubicin BCL2 apoptosis regulator Homo sapiens