Pub. Date : 2018
PMID : 30464588
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-kappaB signal pathway in microglia. | caffeic acid phenethyl ester | mitogen-activated protein kinase 14 | Mus musculus |
| 2 | Our present study investigated the effects and the possible mechanism of caffeic acid phenethyl ester (CAPE), the main ingredient of propolis, in improving neuropathic pain via its inhibition on p38/NF-kappaB signal pathway in microglia. | caffeic acid phenethyl ester | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | Our present study investigated the effects and the possible mechanism of caffeic acid phenethyl ester (CAPE), the main ingredient of propolis, in improving neuropathic pain via its inhibition on p38/NF-kappaB signal pathway in microglia. | caffeic acid phenethyl ester | mitogen-activated protein kinase 14 | Mus musculus |
| 4 | Furthermore, CAPE suppressed the phosphorylation of p38 mitogen-activated protein kinase, inhibited the translocation of NF-kappaB and decreased the expression of proinflammatory cytokines tumor necrosis factor-alpha, IL-1beta and IL-6. | caffeic acid phenethyl ester | mitogen-activated protein kinase 14 | Mus musculus |
| 5 | Conclusion: CAPE was found to be an effective and safe drug candidate for alleviating neuropathic pain by its powerful inhibition on the P38/NF-kappaB signal pathway. | caffeic acid phenethyl ester | mitogen-activated protein kinase 14 | Mus musculus |