Title : Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.

Pub. Date : 2019 Sep

PMID : 30464227






3 Functional Relationships(s)
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1 Importantly, a novel interaction between Vps26a and Nox4 linked to the activation of ERK1/2 depended highly on ROS levels during neurogenesis, which were strongly suppressed in differentiating Vps26a-/- ESCs. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens
2 Moreover, inhibition of phosphorylated ERK1/2 (pERK1/2) resulted in decreased ROS and Nox4 levels, indicating the mutual dependency between pERK1/2 and Nox4-derived ROS during neurogenesis. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens
3 Moreover, inhibition of phosphorylated ERK1/2 (pERK1/2) resulted in decreased ROS and Nox4 levels, indicating the mutual dependency between pERK1/2 and Nox4-derived ROS during neurogenesis. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens