Title : Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system.

Pub. Date : 2018

PMID : 30459926






1 Functional Relationships(s)
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1 Although reactive oxygen species from mitochondria have been reported to be involved in the activation of the NLRP3 inflammasome in microglial cells upon the deposition of Abeta, whether Abeta directly or indirectly activates the NLRP3 inflammasome remains unclear. Reactive Oxygen Species amyloid beta precursor protein Homo sapiens