Pub. Date : 2018 Nov 20
PMID : 30453884
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Searching for variants with evidence of regulatory functions, we have reported interactions between CHRNA5 and CHRNA3 enhancer variants (tagged by rs880395 and rs1948, respectively) and rs16969968, forming 3-SNP haplotypes and diplotypes that may more accurately reflect the cluster"s combined effects on nicotine dependence (Barrie et al., Hum Mutat 38:112-9, 2017). | Nicotine | cholinergic receptor nicotinic alpha 3 subunit | Homo sapiens |
| 2 | CONCLUSIONS: These results indicate rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. | Nicotine | cholinergic receptor nicotinic alpha 3 subunit | Homo sapiens |