Protein Name cholinergic receptor nicotinic alpha 3 subunit
Organism Homo sapiens
Gene ID 1136
Gene Symbol

CHRNA3

UniProt P32297 (ACHA3_HUMAN)
Relationships Total Number of functionally related compound(s) : 16
Total Number of Articles : 60
Description

cholinergic receptor nicotinic alpha 3 subunit

Gene Summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

synonyms
  • neuronal acetylcholine receptor subunit alpha-3
  • cholinergic receptor, nicotinic alpha 3
  • cholinergic receptor, nicotinic, alpha 3 (neuronal)
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Properties