Title : Spray-dried plasma deficient in high-molecular-weight multimers of von Willebrand factor retains hemostatic properties.

Pub. Date : 2019 Feb

PMID : 30450617






2 Functional Relationships(s)
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1 RESULTS: While vWF-ristocetin cofactor activity is significantly decreased (-41.13%; p < .0001) in SpDP, a model of vWF-mediated platelet adhesion to collagen under flow showed enhanced function (+13%; p < .01). Ristocetin von Willebrand factor Homo sapiens
2 The apparent paradox between vWF-ristocetin cofactor assay and vWF-mediated platelet adhesion may be explained by the increase in smaller multimers of vWF in SpDP, producing different outcomes in these assays. Ristocetin von Willebrand factor Homo sapiens