Title : Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.

Pub. Date : 2019 Feb

PMID : 30448990






2 Functional Relationships(s)
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1 In this study, we investigated whether chronic treatment with the mGlu2/3 agonist LY379268 would alter the behavioral response to a phenethylamine hallucinogen, 25CN-NBOH, which acts as a selective 5-HT2A agonist. LY 379268 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
2 The effects of chronic LY379268 on 5-HT2A agonist-induced HTR were evaluated by treating mice with either vehicle or LY379268 (10 mg/kg) for 21 days and measuring 25CN-NBOH-induced HTR 48 h after the final LY379268 treatment. LY 379268 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus