Protein Name 5-hydroxytryptamine (serotonin) receptor 2A
Organism Mus musculus
Gene ID 15558
Gene Symbol


UniProt P35363 (5HT2A_MOUSE), Q543D4 (Q543D4_MOUSE)
Relationships Total Number of functionally related compound(s) : 265
Total Number of Articles : 296

5-hydroxytryptamine (serotonin) receptor 2A

Gene Summary

Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphorylation; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Apr 2022]

  • 5-hydroxytryptamine receptor 2A
  • 5-HT2A receptor
  • 5-hydroxytryptamine 2 receptor
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