Title : Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy.

Pub. Date : 2019 Feb

PMID : 30444022






2 Functional Relationships(s)
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1 In mice with high-fat diet-induced obesity and streptozotocin-induced hyperglycemia, microglia accumulated on the RPE layer, as in those after intravitreal injection of interleukin (IL)-6, which is elevated in ocular fluids of patients with diabetic retinopathy. Streptozocin interleukin 6 Mus musculus
2 As STAT3 inhibition reversed the effects of IL-6-treated microglial cells on the RPE monolayer in vitro, it reduced the recruitment of microglial cells and the production of TNF-alpha in RPE tissues in streptozotocin-treated mice. Streptozocin interleukin 6 Mus musculus