Title : SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer.

Pub. Date : 2019 Feb

PMID : 30443978






2 Functional Relationships(s)
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1 Notably, SIRT5 knockout or inhibition by GW5074 increased LDHB acetylation at K329 and inhibited LDHB activity, which downregulated autophagy and CRC cell growth in vitro and in vivo. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone lactate dehydrogenase B Homo sapiens
2 Notably, SIRT5 knockout or inhibition by GW5074 increased LDHB acetylation at K329 and inhibited LDHB activity, which downregulated autophagy and CRC cell growth in vitro and in vivo. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone lactate dehydrogenase B Homo sapiens