Pub. Date : 2019 Oct
PMID : 30431391
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | According to the X-ray crystal structures of CYP17A1 (including its complexes with inhibitors), it is shown that a hydrogen bond exists between CYP17A1 and its inhibitors (such as abiraterone and TOK-001). | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | According to the X-ray crystal structures of CYP17A1 (including its complexes with inhibitors), it is shown that a hydrogen bond exists between CYP17A1 and its inhibitors (such as abiraterone and TOK-001). | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | In the case of abiraterone binding, the unfilled volume in the active site cavity increases the freedom of movement of abiraterone within CYP17A1, leading to the collective motions of the helices G and B" as well as the breaking of hydrogen bond existing between the 3beta-OH group of abiraterone and N202 of CYP17A1. | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | In the case of abiraterone binding, the unfilled volume in the active site cavity increases the freedom of movement of abiraterone within CYP17A1, leading to the collective motions of the helices G and B" as well as the breaking of hydrogen bond existing between the 3beta-OH group of abiraterone and N202 of CYP17A1. | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |