Title : Severe Neuropathic Pain With Concomitant Administration of Vincristine and Posaconazole.

Pub. Date : 2018 Sep-Oct

PMID : 30429697






1 Functional Relationships(s)
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1 Vincristine is a known CYP3A4 and CYP3A5 substrate, and concomitant administration with fluconazole or voriconazole has been reported to increase vincristine toxicity and peripheral neuropathy, but there is limited literature on posaconazole in this regard. Vincristine cytochrome P450 family 3 subfamily A member 5 Homo sapiens