Pub. Date : 2018 Nov 9
PMID : 30423971
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Our current understanding of adenine nucleotide binding and the mechanisms by which differential adenine nucleotide occupancies activate or inhibit AMPK activity has been largely informed by crystal structures of AMPK in different activity states. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Our current understanding of adenine nucleotide binding and the mechanisms by which differential adenine nucleotide occupancies activate or inhibit AMPK activity has been largely informed by crystal structures of AMPK in different activity states. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Our current understanding of adenine nucleotide binding and the mechanisms by which differential adenine nucleotide occupancies activate or inhibit AMPK activity has been largely informed by crystal structures of AMPK in different activity states. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | Here we provide an overview of AMPK structures, and how these structures, in combination with biochemical, biophysical, and mutational analyses provide insights into the mechanisms of adenine nucleotide binding and AMPK activity modulation. | Adenine Nucleotides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |