Pub. Date : 2019 Feb
PMID : 30414698
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 2 | RESULTS AND LIMITATIONS: From the CRISPR screen, we identified MSH2 as the most significantly enriched gene and mismatch repair as the most significantly enriched pathway that promoted resistance to cisplatin. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 3 | Bladder cancer cells with knockdown of MSH2 showed a reduction in cisplatin-mediated apoptosis. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 4 | Bladder tumors with low MSH2 protein levels, quantified using reverse-phase protein array, showed poorer survival when treated with cisplatin- or carboplatin-based therapy; these results require future validation using immunohistochemistry. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 5 | CONCLUSIONS: We generated in vitro evidence that bladder cancer cell lines depleted of MSH2 are more resistant to cisplatin. | Cisplatin | mutS homolog 2 | Homo sapiens |