Pub. Date : 2018
PMID : 30410928
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We tested a well-known selective inhibitor of caspase-1, AC-YVAD-CMK, which has previously been found to have neuroprotective effects in ICH mice model, to ascertain its effects on the activation of inflammasomes mediated pyroptosis. | ac-yvad | caspase 1 | Mus musculus |
| 2 | Our results showed that AC-YVAD-CMK could reduce caspase-1 activation and inhibit IL-1beta production and maturation, but has no effect on NLRP3 expression, an upstream inflammatory complex. | ac-yvad | caspase 1 | Mus musculus |