Title : Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.

Pub. Date : 2019 Jan 4

PMID : 30409902






2 Functional Relationships(s)
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1 Chemical SIRT1 activators (SIRT1720 and resveratrol) suppressed the PGE2-mediated induction of acetyl-HIF-1alpha, HIF-1alpha, and aromatase. Resveratrol hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Chemical SIRT1 activators (SIRT1720 and resveratrol) suppressed the PGE2-mediated induction of acetyl-HIF-1alpha, HIF-1alpha, and aromatase. Resveratrol hypoxia inducible factor 1 subunit alpha Homo sapiens