Title : Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.

Pub. Date : 1987 Sep 5

PMID : 3040732






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The human chorionic gonadotropin-alpha (CG-alpha) gene is transcriptionally activated by cAMP. Cyclic AMP chromogranin A Homo sapiens
2 Sequencing the CG-alpha 5"-flanking region identified two copies of a palindrome, 5"-TGACGTCA-3", homologous to sequences in other cAMP-responsive genes. Cyclic AMP chromogranin A Homo sapiens
3 These studies suggest that the interaction of a 36-bp enhancer-like element with the homologous promoter represents part of the mechanism of cell-specific expression of the CG-alpha gene and that the enhancer is co-localized with a highly effective cAMP-response element. Cyclic AMP chromogranin A Homo sapiens