Title : TPA induces cytoplasmic alkalinization in human monoblastic U-937 cells without activation of Na+/H+ exchange.

Pub. Date : 1987 Jul

PMID : 3040449






4 Functional Relationships(s)
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1 The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens
2 The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens
3 About 2 min after addition of TPA, pHi started to increase and reached a steady state 10-15 min later. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens
4 The TPA-induced increase in pHi was independent of the presence of extracellular Na+. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens