Protein Name glucose-6-phosphate isomerase
Organism Homo sapiens
Gene ID 2821
Gene Symbol


UniProt P06744 (G6PI_HUMAN), A0A2U3TZU2 (A0A2U3TZU2_HUMAN), B4DE36 (B4DE36_HUMAN)
Relationships Total Number of functionally related compound(s) : 965
Total Number of Articles : 1219

glucose-6-phosphate isomerase

Gene Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

  • glucose-6-phosphate isomerase
  • autocrine motility factor
  • hexose monophosphate isomerase
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