Title : Proteasome Inhibitor-Induced IκB/NF-κB Activation is Mediated by Nrf2-Dependent Light Chain 3B Induction in Lung Cancer Cells.

Pub. Date : 2018 Dec 31

PMID : 30396235






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1 However, we recently found that long-term incubation with proteasome inhibitors (PIs) such as PS-341 or MG132 induces IkappaBalpha degradation via an alternative pathway, lysosome, which results in NF-kappaB activation and confers resistance to PI-induced lung cancer cell death. Bortezomib NFKB inhibitor alpha Homo sapiens