Title : Identification of novel regulatory partners of the glutamate transporter GLT-1.

Pub. Date : 2018 Dec

PMID : 30394597






1 Functional Relationships(s)
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1 GTPase Rac1 was one protein identified, and interfering with its GTP/GDP cycle in mixed primary rat brain cultures affected both the clustering of GLT-1 at the astrocytic processes and the transport kinetics, increasing its uptake activity at low micromolar glutamate concentrations in a manner that was dependent on the effector kinase PAK1 and the actin cytoskeleton. Guanosine Diphosphate Rac family small GTPase 1 Rattus norvegicus