Title : Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells.

Pub. Date : 2018 Oct

PMID : 30393482






3 Functional Relationships(s)
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1 In the present study the effect of IP6 on autophagy-mediated death by modulating the mTOR pathway in HT-29 colon cancer cells was studied. Phytic Acid mechanistic target of rapamycin kinase Homo sapiens
2 mTOR pathway regulates autophagy and incubation with IP6 to HT-29 cells showed decreased expression of p-70S6Kinase, 4-EBP-1 in a time-dependent manner. Phytic Acid mechanistic target of rapamycin kinase Homo sapiens
3 Conclusions: Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway. Phytic Acid mechanistic target of rapamycin kinase Homo sapiens