Title : Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol.

Pub. Date : 1987 Jul

PMID : 3038645






4 Functional Relationships(s)
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1 Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol. Phosphatidylinositols insulin receptor Homo sapiens
2 Phosphorylation of PtdIns occurred with these purified insulin receptor preparations, but this activity was insulin-independent, and the turnover number for PtdIns phosphorylation in the presence of soybean phospholipid was 1/220th as small as the turnover number for the autophosphorylating activity. Phosphatidylinositols insulin receptor Homo sapiens
3 Phosphorylation of PtdIns occurred with these purified insulin receptor preparations, but this activity was insulin-independent, and the turnover number for PtdIns phosphorylation in the presence of soybean phospholipid was 1/220th as small as the turnover number for the autophosphorylating activity. Phosphatidylinositols insulin receptor Homo sapiens
4 These results suggest that although PtdIns can modulate the activity of the insulin receptor kinase, PtdIns phosphorylation itself is not directly involved in this regulation. Phosphatidylinositols insulin receptor Homo sapiens