Pub. Date : 2018 Oct 30
PMID : 30375484
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. | Dexamethasone | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | However, a progressive, irreversible loss of clonogenic growth, whose time of onset was dependent on GR level and Dex dose, was independent of p21Cip1and caused by gradual accumulation of p27Kip1 due to transcriptional activation of p27Kip1 by Dex. | Dexamethasone | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | However, a progressive, irreversible loss of clonogenic growth, whose time of onset was dependent on GR level and Dex dose, was independent of p21Cip1and caused by gradual accumulation of p27Kip1 due to transcriptional activation of p27Kip1 by Dex. | Dexamethasone | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 4 | Extended Dex treatment induces irreversible cell cycle blockade and a senescence phenotype through chronic activation of the p27Kip1 gene in GR overexpressing lung tumor cell populations and hence could improve outcome of surgery/pemetrexed chemotherapy and sensitize tumors to immunotherapy. | Dexamethasone | cyclin dependent kinase inhibitor 1B | Homo sapiens |