Title : Blockade of receptor-mediated cyclic GMP formation by hydroxyeicosatetraenoic acid.

Pub. Date : 1987 Aug

PMID : 3037024






2 Functional Relationships(s)
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1 Receptor-mediated cyclic GMP formation in N1E-115 murine neuroblastoma cells appears to involve oxidative metabolism of arachidonic acid. Arachidonic Acid 5'-nucleotidase, cytosolic II Mus musculus
2 Thus, the mechanism of blockade of receptor-mediated cyclic GMP responses by monoHETEs is likely to be more complex than the simple inhibition of cytosolic mechanisms, e.g., generation of a putative second messenger by lipoxygenase, and may involve also alterations of membrane function accompanying the redistributions of esterified arachidonate. Arachidonic Acid 5'-nucleotidase, cytosolic II Mus musculus