Title : A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells.

Pub. Date : 2019 Jan

PMID : 30359932






1 Functional Relationships(s)
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1 In conclusion, the complex exhibits more potent cytotoxicity than piplartine in a panel of different cancer cells and triggers ROS/ERK/p38-mediated apoptosis in HL-60 cells. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens