Title : PEGylated pUR4/FUD peptide inhibitor of fibronectin fibrillogenesis decreases fibrosis in murine Unilateral Ureteral Obstruction model of kidney disease.

Pub. Date : 2018

PMID : 30356276






3 Functional Relationships(s)
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1 In vivo, PEG-FUD significantly decreased fibronectin by ~70% in UUO kidneys as determined by both IHC and immunoblotting, respectively. peg-fud fibronectin 1 Mus musculus
2 Immunoblotting studies also showed that the fibronectin remaining after PEG-FUD treatment was intact. peg-fud fibronectin 1 Mus musculus
3 We propose that PEG-FUD, a specific inhibitor of fibronectin assembly, may be a candidate therapeutic for the treatment of fibrosis in kidney diseases. peg-fud fibronectin 1 Mus musculus