Title : Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma.

Pub. Date : 2018

PMID : 30355923






4 Functional Relationships(s)
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1 Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3beta Signaling Pathway in Human Hepatocellular Carcinoma. erinacine S glycogen synthase kinase 3 beta Homo sapiens
2 The following study aims to investigate the role of erinacine in the opening of the mitochondrial permeability transition pore (MPTP) in hepatocellular carcinoma (HCC) through the PI3K/Akt/GSK-3beta signaling pathway and highlights the applicability of erinacine in HCC treatments. erinacine S glycogen synthase kinase 3 beta Homo sapiens
3 In addition, Erinacine was found to decrease the mitochondrial membrane potential, expression of PI3K, Akt, GSK-3beta, CyclinD1, Vimentin, beta-catenin, and Bcl-2, cell proliferation, colony formation ability, migration, invasion, and xenograft tumor size, while E-cadherin, Bax, and caspase-9 expression, and cell apoptosis were elevated in a dose-dependent manner. erinacine S glycogen synthase kinase 3 beta Homo sapiens
4 CONCLUSION: The results from the study demonstrated that erinacine induced MPTP opening, facilitates the release of cyt-C, and inhibited cell proliferation, migration, and invasion, while it promotes apoptosis by inactivating the PI3K/Akt/GSK-3beta signaling pathway, preventing the progression of HCC. erinacine S glycogen synthase kinase 3 beta Homo sapiens