Title : Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells.

Pub. Date : 2018 Oct 24

PMID : 30352966






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1 In the present study, we show that secondary resistance occurs also after treatment of p53wt cells with idasanutlin (RG7388, RO5503781), which is the only MDM2 antagonist that has passed phase II and entered phase III clinical trials, so far. RG7388 MDM2 proto-oncogene Homo sapiens