Title : Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium.

Pub. Date : 1987 Jul

PMID : 3035101






6 Functional Relationships(s)
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1 Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium. Inositol thyrotropin releasing hormone Rattus norvegicus
2 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol thyrotropin releasing hormone Rattus norvegicus
3 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol thyrotropin releasing hormone Rattus norvegicus
4 The myo-inositol level of cerebellar cortex reached its nadir (70% of values in untreated control rats) 30 min after addition of TRH and then returned to the control level at 90 min. Inositol thyrotropin releasing hormone Rattus norvegicus
5 In cerebral cortex, both lithium alone and lithium plus TRH significantly reduced the myo-inositol level. Inositol thyrotropin releasing hormone Rattus norvegicus
6 These results suggested that the pharmacological dose of TRH activated phosphatidylinositol turnover in rat cerebellar cortex and subsequently reduced the myo-inositol level in the presence of lithium. Inositol thyrotropin releasing hormone Rattus norvegicus