Pub. Date : 2018
PMID : 30349375
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LINE-1 ORF-1p increased the transcription factor activity of PXR by interacting with PXR and enhancing its cytoplasmic/nuclear translocation, and recruiting PXR to its downstream gene promoter, in turn enhancing the expression of the sorafenib resistance-related genes, CYP3A4 and mdr-1. | Sorafenib | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | LINE-1 ORF-1p increased the transcription factor activity of PXR by interacting with PXR and enhancing its cytoplasmic/nuclear translocation, and recruiting PXR to its downstream gene promoter, in turn enhancing the expression of the sorafenib resistance-related genes, CYP3A4 and mdr-1. | Sorafenib | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | LINE-1 ORF-1p increased the transcription factor activity of PXR by interacting with PXR and enhancing its cytoplasmic/nuclear translocation, and recruiting PXR to its downstream gene promoter, in turn enhancing the expression of the sorafenib resistance-related genes, CYP3A4 and mdr-1. | Sorafenib | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | Conclusion: LINE-1 ORF-1p enhances the transcription factor activation of PXR and promotes the clearance of and resistance to sorafenib in HCC cells. | Sorafenib | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |