Title : Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance.

Pub. Date : 2018 Oct 21

PMID : 30347860






3 Functional Relationships(s)
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1 Actively targeted cisplatin micelles were prepared through surface modification of acetal-poly(ethylene oxide)-poly(alpha-carboxyl-epsilon-caprolactone) (acetal-PEO-PCCL) micelles with epidermal growth factor receptor (EGFR)-targeting peptide, GE11 (YHWYGYTPQNVI). Cisplatin epidermal growth factor receptor Homo sapiens
2 Actively targeted cisplatin micelles were prepared through surface modification of acetal-poly(ethylene oxide)-poly(alpha-carboxyl-epsilon-caprolactone) (acetal-PEO-PCCL) micelles with epidermal growth factor receptor (EGFR)-targeting peptide, GE11 (YHWYGYTPQNVI). Cisplatin epidermal growth factor receptor Homo sapiens
3 A significant increase in micellar cisplatin uptake was observed in MDA-MB-231 cells that overexpress EGFR, following surface modification of micelles with GE11. Cisplatin epidermal growth factor receptor Homo sapiens