Title : The antiangiogenic action of cisplatin on endothelial cells is mediated through the release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells.

Pub. Date : 2018 Sep 25

PMID : 30344920






5 Functional Relationships(s)
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1 The antiangiogenic action of cisplatin on endothelial cells is mediated through the release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Cisplatin TIMP metallopeptidase inhibitor 1 Homo sapiens
2 siRNA approaches revealed cisplatin-induced expression and subsequent release of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) by lung cancer cells to be causally linked to a decrease in HUVEC migration and tube formation. Cisplatin TIMP metallopeptidase inhibitor 1 Homo sapiens
3 siRNA approaches revealed cisplatin-induced expression and subsequent release of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) by lung cancer cells to be causally linked to a decrease in HUVEC migration and tube formation. Cisplatin TIMP metallopeptidase inhibitor 1 Homo sapiens
4 Moreover, TIMP-1 upregulation and consequent inhibition of HUVEC migration by cisplatin was shown to be dependent on activation of p38 and p42/44 mitogen-activated protein kinases. Cisplatin TIMP metallopeptidase inhibitor 1 Homo sapiens
5 Collectively, the present data suggest a pivotal role of cisplatin-induced TIMP-1 release from lung cancer cells in tumor-to-endothelial cell communication resulting in a reduced cancer-associated angiogenic impact on endothelial cells. Cisplatin TIMP metallopeptidase inhibitor 1 Homo sapiens