Title : Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study.

Pub. Date : 2019 Feb

PMID : 30343043






2 Functional Relationships(s)
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1 Also, lapatinib strongly activated AKT but suppressed EGFR in MDA-MB231 cells. Lapatinib epidermal growth factor receptor Homo sapiens
2 CONCLUSION: By way of its multikinase inhibitory effects, berberine might be a useful replacement for lapatinib, an EGFR inhibitor which can cause acquired drug resistance in patients. Lapatinib epidermal growth factor receptor Homo sapiens