Title : Reversing effects of ginsenosides on LPS-induced hepatic CYP3A11/3A4 dysfunction through the pregnane X receptor.

Pub. Date : 2019 Jan 30

PMID : 30342195






2 Functional Relationships(s)
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1 To further investigate the regulatory mechanisms, we found that ginsenosides enhanced the rifampicin-induced pregnane X receptor (PXR) transactivation of the CYP3A4 promoter. Ginsenosides cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Treatment of hPXR-over-expressed cells with ginsenosides increased the rifampicin-inducible expression of CYP3A4 in a concentration-dependent manner. Ginsenosides cytochrome P450 family 3 subfamily A member 4 Homo sapiens