Title : Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

Pub. Date : 2019 Feb

PMID : 30342037






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 AURKA knockdown or inhibition with alisertib reduced levels of phosphorylated RPS6KB1 (at T389) and increased levels of proteins that induce apoptosis, including BIM, cleaved PARP, and cleaved caspase 3. MLN 8237 poly(ADP-ribose) polymerase 1 Homo sapiens