Title : vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation.

Pub. Date : 2018 Nov

PMID : 30337247






1 Functional Relationships(s)
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1 FINDINGS: Both rLep-vWA-I and rLep-vWA-II were able to bind to Hu-platelets and inhibit rHu-vWF/ristocetin-induced Hu-platelet aggregation, but Hu-GPIbalpha-IgG, rLep-vWA-I-IgG and rLep-vWA-II-IgG blocked this binding or inhibition. Ristocetin von Willebrand factor Homo sapiens