Pub. Date : 2018 Oct 17
PMID : 30336548
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nafamostat mesilate (FUT175), a synthetic serine protease inhibitor, enhances the chemosensitivity to cytotoxic agents in digestive system cancer cells by inhibiting NF-kappaB activation. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Nafamostat mesilate (FUT175), a synthetic serine protease inhibitor, enhances the chemosensitivity to cytotoxic agents in digestive system cancer cells by inhibiting NF-kappaB activation. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | IR-induced upregulation of intranuclear NF-kappaB, FUT175 counteracted this effect. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In conclusion, FUT175 enhances the anti-tumor effect of radiotherapy through downregulation of NF-kappaB and reduces IR-induced tumor invasiveness by directly inhibiting MMP-2/-9 in CRC cells. | nafamostat | nuclear factor kappa B subunit 1 | Homo sapiens |