Title : Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells.

Pub. Date : 2018 Oct 17

PMID : 30336548






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nafamostat mesilate (FUT175), a synthetic serine protease inhibitor, enhances the chemosensitivity to cytotoxic agents in digestive system cancer cells by inhibiting NF-kappaB activation. nafamostat nuclear factor kappa B subunit 1 Homo sapiens
2 Nafamostat mesilate (FUT175), a synthetic serine protease inhibitor, enhances the chemosensitivity to cytotoxic agents in digestive system cancer cells by inhibiting NF-kappaB activation. nafamostat nuclear factor kappa B subunit 1 Homo sapiens
3 IR-induced upregulation of intranuclear NF-kappaB, FUT175 counteracted this effect. nafamostat nuclear factor kappa B subunit 1 Homo sapiens
4 In conclusion, FUT175 enhances the anti-tumor effect of radiotherapy through downregulation of NF-kappaB and reduces IR-induced tumor invasiveness by directly inhibiting MMP-2/-9 in CRC cells. nafamostat nuclear factor kappa B subunit 1 Homo sapiens