Pub. Date : 1987 May 11
PMID : 3033417
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric acid on alpha-MSH release from neurointermediate lobes in vitro. | gamma-Aminobutyric Acid | proopiomelanocortin | Homo sapiens |
| 2 | High doses of GABA (10(-5) and 10(-4) M) induced a biphasic effect on pars intermedia cells: a brief stimulation followed by a sustained inhibition of alpha-MSH secretion. | gamma-Aminobutyric Acid | proopiomelanocortin | Homo sapiens |
| 3 | Administration of clonazepam (10(-5) M) in the presence of various concentrations of GABA (10(-6) to 10(-4) M) led to a potentiation of both stimulatory and inhibitory phases of alpha-MSH secretion induced by GABA. | gamma-Aminobutyric Acid | proopiomelanocortin | Homo sapiens |
| 4 | Administration of clonazepam (10(-5) M) in the presence of various concentrations of GABA (10(-6) to 10(-4) M) led to a potentiation of both stimulatory and inhibitory phases of alpha-MSH secretion induced by GABA. | gamma-Aminobutyric Acid | proopiomelanocortin | Homo sapiens |
| 5 | Thus our results indicate that endogenous benzodiazepine receptors may modulate the effects of GABA on alpha-MSH secretion. | gamma-Aminobutyric Acid | proopiomelanocortin | Homo sapiens |