Pub. Date : 2018 Dec 7
PMID : 30333228
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | Here, we report that NAD+ cleavage activity of SARM1 is regulated by its own phosphorylation at serine 548. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | The phosphorylation of SARM1 was mediated by c-jun N-terminal kinase (JNK) under oxidative stress conditions, resulting in inhibition of mitochondrial respiration concomitant with enhanced activity of NAD+ cleavage. | NAD | sterile alpha and TIR motif containing 1 | Homo sapiens |