Title : Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions.

Pub. Date : 2019 Jun

PMID : 30327544






3 Functional Relationships(s)
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Protein Name
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1 The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L). Ginsenosides solute carrier organic anion transporter family member 1B3 Homo sapiens
2 The protopanaxadiol-type ginsenosides, ginsenosides without any sugar attachment at C-20 (except ginsenoside Rf), and ginsenoside Ro inhibited OATP1B3 more potently (IC50, 0.2-3.5 micromol/L) than the other ginsenosides (>=22.6 micromol/L). Ginsenosides solute carrier organic anion transporter family member 1B3 Homo sapiens
3 Ginsenosides Rb1, Rb2, Rc, Rd, Ro, Ra1, Re, and Rg2 likely contribute the major part of OATP1B3-mediated ShenMai-drug interaction potential, in an additive and time-related manner. Ginsenosides solute carrier organic anion transporter family member 1B3 Homo sapiens