Title : The inhibitory effect of pyrogallol on tyrosinase activity and structure: Integration study of inhibition kinetics with molecular dynamics simulation.

Pub. Date : 2019 Jan

PMID : 30326223






2 Functional Relationships(s)
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1 In this study, we evaluated the dual effect of pyrogallol on tyrosinase as an inhibitor in the presence of L-DOPA simultaneously via integrating methods of enzyme kinetics and computational molecular dynamics (MD) simulations. Levodopa tyrosinase Homo sapiens
2 Pyrogallol was found to be a reversible inhibitor of tyrosinase in the presence of L-DOPA and its induced mechanism was the parabolic non-competitive inhibition type (IC50 = 0.772 +- 0.003 mM and Ki = 0.529 +- 0.022 mM). Levodopa tyrosinase Homo sapiens