Title : Inhibition of extracellular signal-regulated kinase potentiates the apoptotic and antimetastatic effects of cyclin-dependent kinase inhibitors on metastatic DU145 and PC3 prostate cancer cells.

Pub. Date : 2019 Apr

PMID : 30320903






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 This study provides biological evidence about purvalanol and roscovitine have apoptotic and antimetastatic effects via MAPK signaling on prostate cancer cell by activation of GSK3beta signaling and inhibition of phosphoinositide-3-kinase/AKT (PI3K/AKT) pathways involved in the EMT process. purvalanol B phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens