Pub. Date : 2018 Sep
PMID : 30320189
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats. | Resveratrol | Janus kinase 2 | Rattus norvegicus |
| 2 | The results suggested that resveratrol significantly improved neurological function, reduced cerebral infarct volume, decreased neuronal damage, and markedly attenuated neuronal apoptosis; these effects were attenuated by the inhibition of PI3K/AKT with LY294002 and JAK2/STAT3 with AG490. | Resveratrol | Janus kinase 2 | Rattus norvegicus |
| 3 | We also found that resveratrol significantly upregulated the expression of p-JAK2, p-STAT3, p-AKT, p-mTOR, and BCL-2 and downregulated expression of cleaved caspase-3 and BAX, which was partially reversed by LY294002 and AG490. | Resveratrol | Janus kinase 2 | Rattus norvegicus |
| 4 | These results suggested that resveratrol provides a neuroprotective effect against cerebral ischemia/reperfusion injury, which is partially mediated by the activation of JAK2/STAT3 and PI3K/AKT/mTOR. | Resveratrol | Janus kinase 2 | Rattus norvegicus |
| 5 | Resveratrol may indirectly upregulate the PI3K/AKT/mTOR pathway by activating JAK2/STAT3. | Resveratrol | Janus kinase 2 | Rattus norvegicus |