Title : Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Pub. Date : 2019 Feb 5

PMID : 30318339






1 Functional Relationships(s)
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1 Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Reactive Oxygen Species interleukin 6 Homo sapiens