Pub. Date : 2019 Apr
PMID : 30317677
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long noncoding RNA growth arrest-specific 5 facilitates glioma cell sensitivity to cisplatin by suppressing excessive autophagy in an mTOR-dependent manner. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | In addition, GAS5 restored cisplatin-inhibited mammalian target of rapamycin (mTOR) activation. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | In addition, GAS5 restored cisplatin-inhibited mammalian target of rapamycin (mTOR) activation. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Preconditioning with mTOR antagonist rapamycin engendered not only mTOR inhibition but also abrogated GAS5-mediated depression in cisplatin-evoked autophagy. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | Notably, blocking the mTOR pathway also attenuated GAS5-increased sensitivity to cisplatin in U138 cells. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |