Pub. Date : 2019 Apr
PMID : 30317657
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. | Nicotine | interleukin 6 | Homo sapiens |
| 2 | In this study, we investigated the effects of nicotine, a major psychoactive compound in cigarette smoke, on IL-6 expression and EA.hy926 endothelial cell invasion. | Nicotine | interleukin 6 | Homo sapiens |
| 3 | Nicotine stimulated IL-6 expression via the activator protein 1 (AP-1) transcription factor. | Nicotine | interleukin 6 | Homo sapiens |
| 4 | Pharmacological inhibition and mutagenesis studies indicated that p38 mitogen-activated protein kinase (MAPK) mediated the IL-6-induced upregulation of nicotine in EA.hy926 cells. | Nicotine | interleukin 6 | Homo sapiens |
| 5 | Furthermore, the antioxidant compound N-acetyl-cysteine eliminated the nicotine-activated production of reactive oxygen species (ROS) and inhibited signal transducer and activator of transcription 3 (STAT-3) phosphorylation; these two mechanisms mediated the upregulation of IL-6 expression by nicotine. | Nicotine | interleukin 6 | Homo sapiens |
| 6 | In addition, the EA.hy926 cells treated with nicotine displayed markedly enhanced invasiveness due to IL-6 upregulation. | Nicotine | interleukin 6 | Homo sapiens |
| 7 | Our data demonstrate that nicotine induced IL-6 expression, which, in turn, enhanced the invasiveness of endothelial EA.hy926 cells, via activation of the p38 MAPK/AP-1 and ROS/STAT-3 signaling pathways. | Nicotine | interleukin 6 | Homo sapiens |