Title : Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

Pub. Date : 1987 Mar

PMID : 3031644






4 Functional Relationships(s)
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1 In cultured human ovarian granulosa cells, follicle-stimulating hormone, human chorionic gonadotropin, and dibutyryl cAMP increased IGF-II mRNA, but corticotropin [adrenocorticotropic hormone (ACTH)], chorionic somatomammotropin, growth hormone, prolactin, dexamethasone, estradiol, and progesterone had no effect. Cyclic AMP insulin like growth factor 2 Homo sapiens
2 In cultured human fetal adrenal cells, ACTH and dibutyryl cAMP increased IGF-II mRNA accumulation, but human chorionic gonadotropin and angiotensin II did not. Cyclic AMP insulin like growth factor 2 Homo sapiens
3 Dibutyryl cAMP also increased IGF-II mRNA accumulation in cultured human placental cells. Cyclic AMP insulin like growth factor 2 Homo sapiens
4 The data indicate that the IGF-II gene is expressed in human steroidogenic tissues and is regulated by cAMP. Cyclic AMP insulin like growth factor 2 Homo sapiens