Title : AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis.

Pub. Date : 2019 Jan

PMID : 30315766






1 Functional Relationships(s)
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1 ROS have been shown to stabilize hypoxia-inducible factor (HIF)-1alpha, which, in turn, may induce transcription of antiangiogenic factors, soluble fms-like tyrosine kinase 1 (sFLT1), and soluble endoglin in trophoblasts. Reactive Oxygen Species hypoxia inducible factor 1 subunit alpha Homo sapiens